Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical community. Although a lot of experimental effort was...

Full description

Bibliographic Details
Main Authors: Judith J. Mittag, Marie-Luise Trutschel, Helen Kruschwitz, Karsten Mäder, Julia Buske, Patrick Garidel
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
EPR
Polysorbate
Radical
Oxidation
Peroxide
Spin trap
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156722000123

Internet

http://www.sciencedirect.com/science/article/pii/S2590156722000123

Similar Items