Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling

Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. Real-time RT-PCR and western blot were used to investigate whether the down-regulation of Notch-1 contributes...

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Bibliographic Details
Main Authors: Yang Chen, Xiang-Zhen Han, Wei Wang, Ren-Tao Zhao, Xiao Li
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2014-08-01
Series:Bangladesh Journal of Pharmacology
Subjects:
Online Access:https://www.banglajol.info/index.php/BJP/article/view/19568