Pharmacological Inhibition and Activation of the Ca<sup>2+</sup> Activated Cl<sup>−</sup> Channel TMEM16A

Pharmacological Inhibition and Activation of the Ca<sup>2+</sup> Activated Cl<sup>−</sup> Channel TMEM16A

TMEM16A is a Ca<sup>2+</sup> activated Cl<sup>−</sup> channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl<sup>−</sup> secretion and to en...

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Bibliographic Details
Main Authors: Raquel Centeio, Inês Cabrita, Roberta Benedetto, Khaoula Talbi, Jiraporn Ousingsawat, Rainer Schreiber, John K. Sullivan, Karl Kunzelmann
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
TMEM16A
TMEM16F
benzbromarone
niclosamide
Ani9
TMEM16A potentiators
Online Access:https://www.mdpi.com/1422-0067/21/7/2557

Internet

https://www.mdpi.com/1422-0067/21/7/2557

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