ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development

ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development

To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from the angiotensin II (Ang II)-HFD-ApoE-KO aneurysm model and made significant findings: 1) Ang II bypassed HFD-induced metaboli...

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Bibliographic Details
Main Authors: Yifan Lu, Yu Sun, Fatma Saaoud, Ying Shao, Keman Xu, Xiaohua Jiang, Sheng Wu, Jun Yu, Nathaniel W. Snyder, Ling Yang, Xinghua Mindy Shi, Huaqing Zhao, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
Ang II
ER stress
metabolic reprogramming
vascular inflammation
trained immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268916/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268916/full

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