Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity

Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity

Abstract The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells eliminates clock function and diminishes hypoxic g...

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Bibliographic Details
Main Authors: Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang, Hongguang Shao, Harsh Dweep, Yao-Yu Gong, Rebekah Brooks, Patricia Brafford, Adam J. Wolpaw, Yool Lee, Ashani Weeraratna, Amita Sehgal, Meenhard Herlyn, Andrew Kossenkov, David Speicher, Peter K. Sorger, Sandro Santagata, Chi V. Dang
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44778-2

Internet

https://doi.org/10.1038/s41467-024-44778-2

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