Enhancement of HSA-pFSHβ production by disrupting YPS1 and supplementing N-acetyl-L-cysteine in Pichia pastoris

Enhancement of HSA-pFSHβ production by disrupting YPS1 and supplementing N-acetyl-L-cysteine in Pichia pastoris

IntroductionPichia pastoris is widely used for the production of recombinant proteins, but the low production efficiency hinders its wide application in biopharmaceuticals. Moreover, many biopharmaceutical-like proteins are accompanied by degradation during secretory expression in P. pastoris.Object...

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Bibliographic Details
Main Authors: Gang Luo, Zijian Geng, Buayisham Kuerban, Yingqing Xu, Jingjing Yang, Jiying Liu, Muwang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
Pichia pastoris
follicle-stimulating hormone
YPS1
NAC
YPT7
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.998647/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.998647/full

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