The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand

The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand

Objective: The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (MNADK) mediates de novo mitochondrial NADP biosynthesis by catalyzing the phosphorylation of NAD to yield NADP. In this study, we investigated the function and mechanistic basis by which MNADK regulates metabolic homeostasi...

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Bibliographic Details
Main Authors: Hyunbae Kim, Zhiyao Fu, Zhao Yang, Zhenfeng Song, El Hussain Shamsa, Thangal Yumnamcha, Shengyi Sun, Wanqing Liu, Ahmed S. Ibrahim, Nathan R. Qi, Ren Zhang, Kezhong Zhang
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Molecular Metabolism
Subjects:
Energy metabolism
MNADK
Mitochondrial metabolism
Acetylation
Metabolic transcription factors
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001314

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822001314

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