Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis

Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis

Summary: Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs containing Kupffer cells (KuLOs) by recapitulating fe...

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Bibliographic Details
Main Authors: Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002468

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http://www.sciencedirect.com/science/article/pii/S2211124724002468

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