Mechanistic Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Potential, Limitations, and Perspectives

Mechanistic Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Potential, Limitations, and Perspectives

Several elements highlight the importance of the mechanistic target of rapamycin (mTOR) in the biology of renal cell carcinoma (RCC). mTOR signaling pathway is indeed frequently activated in RCC, inducing cancer cell proliferation and survival. In addition, mTOR promotes tumor angiogenesis and regul...

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Bibliographic Details
Main Authors: Seraina Faes, Nicolas Demartines, Olivier Dormond
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mTOR
rapalogs
renal cell carcinoma
HIF-α
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.636037/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.636037/full

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