A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4.

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4.

Prostate cancer (PCa) is the second highest cause of cancer death in United States males. If the metastatic movement of PCa cells could be inhibited, then mortality from PCa could be greatly reduced. Mitogen-activated protein kinase kinase 4 (MAP2K4) has previously been shown to activate pro-invasio...

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Bibliographic Details
Main Authors: Sankar N Krishna, Chi-Hao Luan, Rama K Mishra, Li Xu, Karl A Scheidt, Wayne F Anderson, Raymond C Bergan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855329?pdf=render

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http://europepmc.org/articles/PMC3855329?pdf=render

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