Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is p...

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Bibliographic Details
Main Authors: Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
histone pre-mRNA 3' end processing
MBL domain containing protein 1
S-phase
endoribonuclease
metallo β-lactamase
Online Access:https://elifesciences.org/articles/39865

Internet

https://elifesciences.org/articles/39865

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