Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is p...
Main Authors: | Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/39865 |
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