Metabolic correlates to critical speed in murine models of sickle cell disease

Metabolic correlates to critical speed in murine models of sickle cell disease

Introduction: Exercise intolerance is a common clinical manifestation in patients with sickle cell disease (SCD), though the mechanisms are incompletely understood.Methods: Here we leverage a murine mouse model of sickle cell disease, the Berkeley mouse, to characterize response to exercise via dete...

Full description

Bibliographic Details
Main Authors: Francesca I. Cendali, Travis Nemkov, Christina Lisk, Ian S. Lacroix, Seyed-Mehdi Nouraie, Yingze Zhang, Victor R. Gordeuk, Paul W. Buehler, David Irwin, Angelo D’Alessandro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
critical speed
sickle cell disease
exercise
metabolism
carnitines
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1151268/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1151268/full

Similar Items