PP2A regulates metastasis and vasculogenic mimicry formation via PI3K/AKT/ZEB1 axis in non-small cell lung cancers

PP2A regulates metastasis and vasculogenic mimicry formation via PI3K/AKT/ZEB1 axis in non-small cell lung cancers

Studies have shown that inhibition of PI3K/AKT signaling is a key strategy for the treatment of tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Vasculogenic mimicry (VM) not only accelerates tumor progression but also increases drug-induced resistance. As a tumor suppress...

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Bibliographic Details
Main Authors: Yu Zhang, Xingchen Wang, Anqi Li, Yanhui Guan, Peibo Shen, Yingqian Ni, Xiuzhen Han
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Pharmacological Sciences
Subjects:
NSCLC
PP2A
ZEB1
VE-cadherin
VM
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000512

Internet

http://www.sciencedirect.com/science/article/pii/S1347861322000512

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