Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy

Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy

Spinal and Bulbar Muscular Atrophy (SBMA) is an X-linked adult-onset progressive neuromuscular disease that affects the spinal and bulbar motor neurons and skeletal muscles. SBMA is caused by expansion of polymorphic CAG trinucleotide repeats in the Androgen Receptor (AR) gene, resulting in expanded...

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Bibliographic Details
Main Authors: Neha Gogia, Luhan Ni, Victor Olmos, Fatema Haidery, Kimberly Luttik, Janghoo Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal and bulbar muscular atrophy (SBMA)
androgen receptor (AR)
posttranslational modification (PTM)
neurodegeneration
polyglutamine disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.931301/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.931301/full

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