The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade. However, detecting and correcting the discrepancy...

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Bibliographic Details
Main Authors: Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
immune receptor repertoire
high-throughput sequencing
multiplex PCR
PCR bias correction
adaptive immunity
TCR
Online Access:https://elifesciences.org/articles/69157

Internet

https://elifesciences.org/articles/69157

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