<named-content content-type="genus-species">Staphylococcus aureus</named-content> Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages

<named-content content-type="genus-species">Staphylococcus aureus</named-content> Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages

ABSTRACT Macrophages are critical to innate immunity due to their ability to phagocytose bacteria. The macrophage phagolysosome is a highly acidic organelle with potent antimicrobial properties, yet remarkably, ingested Staphylococcus aureus replicates within this niche. Herein we demonstrate that S...

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Bibliographic Details
Main Authors: Ronald S. Flannagan, Robert C. Kuiack, Martin J. McGavin, David E. Heinrichs
Format: Article
Language:English
Published: American Society for Microbiology 2018-09-01
Series:mBio
Subjects:
antimicrobial peptides
host-pathogen
intracellular bacteria
macrophages
phagocytosis
phagolysosome
Online Access:https://journals.asm.org/doi/10.1128/mBio.01143-18

Internet

https://journals.asm.org/doi/10.1128/mBio.01143-18

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