Accurate prediction of functional effect of single amino acid variants with deep learning

Accurate prediction of functional effect of single amino acid variants with deep learning

The assessment of functional effect of amino acid variants is a critical biological problem in proteomics for clinical medicine and protein engineering. Although natively occurring variants offer insights into deleterious variants, high-throughput deep mutational experiments enable comprehensive inv...

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Bibliographic Details
Main Authors: Houssemeddine Derbel, Zhongming Zhao, Qian Liu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Functional effect
Deep learning
Single amino acid variant
Precise estimation
High-throughput experiments
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023004312

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http://www.sciencedirect.com/science/article/pii/S2001037023004312

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