Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci

Abstract Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses. We developed an efficient means of conducting genome-wide association studies using combinations...

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Detalhes bibliográficos
Main Authors: Thomas H. McCoy, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart, Roy H. Perlis
Formato: Artigo
Idioma:English
Publicado em: BMC 2017-08-01
Colecção:Molecular Medicine
Acesso em linha:http://link.springer.com/article/10.2119/molmed.2017.00100