Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA

Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA

The virulence of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), depends on the expression of toxins and virulence factors controlled by the quorum-sensing (QS) system, encoded on the virulence accessory gene regulator (agr) locus. The aim of this study was to identify a phy...

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Bibliographic Details
Main Authors: Junpei Yamaguchi, Teruhisa Manome, Yasumasa Hara, Yuriko Yamazaki, Yuumi Nakamura, Masami Ishibashi, Akiko Takaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
physalins
MRSA
Agr-QS modulator
anti-hemolytic activity
AgrA-DNA inhibition
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1365815/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1365815/full

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