Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth

Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth

Abstract Background The MYC oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others. MYC is overexpressed in approximately 70% of hu...

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Bibliographic Details
Main Authors: Yan Xiong, Lulu Wang, Shiyao Xu, Beibei Fu, Yuchen Che, Mohamed Y. Zaky, Rong Tian, Rui Yao, Dong Guo, Zhou Sha, Feng Lin, Xiaoyuan Lin, Haibo Wu
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Clinical and Translational Medicine
Subjects:
co‐regulation
phosphorylation
TAF10
TRIP12
ubiquitination
Online Access:https://doi.org/10.1002/ctm2.1153

Internet

https://doi.org/10.1002/ctm2.1153

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