Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain

Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain

Background: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization. This study aimed to determine the role of netrin-1 from the metastatic bone microenvironment in BCP development and identify t...

Full description

Bibliographic Details
Main Authors: Zhihao Gong, Yuxin Zhang, Wei Wang, Xin Li, Kai Wang, Xingji You, Jingxiang Wu
Format: Article
Language:English
Published: IMR Press 2024-02-01
Series:Journal of Integrative Neuroscience
Subjects:
bone cancer pain
netrin-1
dcc
fak
rac1/cdc42
cgrp
axonal guidance
neurite elongation
nociception
Online Access:https://www.imrpress.com/journal/JIN/23/3/10.31083/j.jin2303047

Internet

https://www.imrpress.com/journal/JIN/23/3/10.31083/j.jin2303047

Similar Items