Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects against dengue virus infection in mice

Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects against dengue virus infection in mice

Objective: To evaluate the expression of DNA plasmid-harboring modified antibody gene that produces neutralizing human monoclonal antibodies against four serotypes of dengue virus (DENV) without enhancing activity in BALB/c mice. Methods: We constructed pFUSE-based vectors (pFUSE_1G7C2_ hVH and pFUS...

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Bibliographic Details
Main Authors: Surachet Benjathummarak, Atsushi Yamanaka, Thanyaluk Krasae, Chonlatip Pipattanaboon, Subenya Injampa, Pannamthip Pitaksajjakul, Pongrama Ramasoota
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
dengue virus; lala mutation; antibody-dependent enhancement (ade); antibody plasmid; electroporation
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=7;spage=299;epage=308;aulast=Benjathummarak

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http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=7;spage=299;epage=308;aulast=Benjathummarak

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