Differential role of signal 3 inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

Differential role of signal 3 inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

Following an infection, naïve CD8 T cells are stimulated by dendritic cells displaying pathogen-derived peptides on MHC-class I molecules (signal 1) and costimulatory molecules (signal 2). Additionally, pathogen-induced inflammatory cytokines also act directly on the responding CD8 T cells...

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Bibliographic Details
Main Authors: Nhat-Long ePham, Vladimir eBadovinac, John eHarty
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-02-01
Series:Frontiers in Immunology
Subjects:
CD8 T cells
inflammatory cytokines
effector/memory differentiation
signal 3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00004/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00004/full

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