Differential role of signal 3 inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

Differential role of signal 3 inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

Following an infection, naïve CD8 T cells are stimulated by dendritic cells displaying pathogen-derived peptides on MHC-class I molecules (signal 1) and costimulatory molecules (signal 2). Additionally, pathogen-induced inflammatory cytokines also act directly on the responding CD8 T cells...

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Bibliographic Details
Main Authors:	Nhat-Long ePham, Vladimir eBadovinac, John eHarty
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-02-01
Series:	Frontiers in Immunology
Subjects:	CD8 T cells inflammatory cytokines effector/memory differentiation signal 3
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00004/full

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