Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations

IntroductionHeterozygous mutations in GBA1, which encodes the lysosomal hydrolase glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement disorder Parkinson's disease (PD). Consequently, therapeutic options targeting the GCase enzyme are in development. An import...

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Bibliographic Details
Main Authors: Adahir Labrador-Garrido, Siying Zhong, Laura Hughes, Shikara Keshiya, Woojin S. Kim, Glenda M. Halliday, Nicolas Dzamko
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson's disease
GCase
alpha-synuclein
pluripotent stem cells
LRRK2
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1229213/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1229213/full

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