Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D li...

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Bibliographic Details
Main Authors: Stefanie Maurer, Korbinian Nepomuk Kropp, Gerd Klein, Alexander Steinle, Sebastian P. Haen, Juliane S. Walz, Clemens Hinterleitner, Melanie Märklin, Hans-Georg Kopp, Helmut Rainer Salih
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:OncoImmunology
Subjects:
cancer
immune-surveillance
metastasis
nk cells
platelets
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1364827

Internet

http://dx.doi.org/10.1080/2162402X.2017.1364827

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