Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

Fibroblast growth factor 2 (FGF2) is a heparin-binding growth factor with broad mitogenic and cell survival activities. Its effector functions are induced upon the formation of 2:2 FGF2:FGFR1 tetrameric complex. To facilitate receptor activation, and therefore, to improve the FGF2 biological propert...

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Bibliographic Details
Main Authors: Daria Nawrocka, Mateusz Adam Krzyscik, Łukasz Opaliński, Malgorzata Zakrzewska, Jacek Otlewski
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
FGF2
dimerization
PEGylation
chemical conjugation
regenerative medicine
growth factors
Online Access:https://www.mdpi.com/1422-0067/21/11/4108

Internet

https://www.mdpi.com/1422-0067/21/11/4108

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