Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review
Riboflavin (vitamin B<sub>2</sub>) is one of the essential vitamins that the human body needs to maintain normal metabolism. Its biosynthesis has become one of the successful models for gradual replacement of traditional chemical production routes. <i>B. subtilis</i> is chara...
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MDPI AG
2023-01-01
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author | Yang Liu Quan Zhang Xiaoxiao Qi Huipeng Gao Meng Wang Hao Guan Bo Yu |
author_facet | Yang Liu Quan Zhang Xiaoxiao Qi Huipeng Gao Meng Wang Hao Guan Bo Yu |
author_sort | Yang Liu |
collection | DOAJ |
description | Riboflavin (vitamin B<sub>2</sub>) is one of the essential vitamins that the human body needs to maintain normal metabolism. Its biosynthesis has become one of the successful models for gradual replacement of traditional chemical production routes. <i>B. subtilis</i> is characterized by its short fermentation time and high yield, which shows a huge competitive advantage in microbial fermentation for production of riboflavin. This review summarized the advancements of regulation on riboflavin production as well as the synthesis of two precursors of ribulose-5-phosphate riboflavin (Ru5P) and guanosine 5′-triphosphate (GTP) in <i>B. subtilis</i>. The different strategies to improve production of riboflavin by metabolic engineering were also reviewed. |
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issn | 2076-2607 |
language | English |
last_indexed | 2024-03-09T11:38:35Z |
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spelling | doaj.art-c89bfb9ca7384c7c97b5880164d64d902023-11-30T23:37:22ZengMDPI AGMicroorganisms2076-26072023-01-0111116410.3390/microorganisms11010164Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A ReviewYang Liu0Quan Zhang1Xiaoxiao Qi2Huipeng Gao3Meng Wang4Hao Guan5Bo Yu6Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, ChinaKey Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, ChinaCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, ChinaKey Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, ChinaKey Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, ChinaCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaRiboflavin (vitamin B<sub>2</sub>) is one of the essential vitamins that the human body needs to maintain normal metabolism. Its biosynthesis has become one of the successful models for gradual replacement of traditional chemical production routes. <i>B. subtilis</i> is characterized by its short fermentation time and high yield, which shows a huge competitive advantage in microbial fermentation for production of riboflavin. This review summarized the advancements of regulation on riboflavin production as well as the synthesis of two precursors of ribulose-5-phosphate riboflavin (Ru5P) and guanosine 5′-triphosphate (GTP) in <i>B. subtilis</i>. The different strategies to improve production of riboflavin by metabolic engineering were also reviewed.https://www.mdpi.com/2076-2607/11/1/164riboflavinbiosynthesis<i>Bacillus subtilis</i>metabolic engineering |
spellingShingle | Yang Liu Quan Zhang Xiaoxiao Qi Huipeng Gao Meng Wang Hao Guan Bo Yu Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review Microorganisms riboflavin biosynthesis <i>Bacillus subtilis</i> metabolic engineering |
title | Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review |
title_full | Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review |
title_fullStr | Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review |
title_full_unstemmed | Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review |
title_short | Metabolic Engineering of <i>Bacillus subtilis</i> for Riboflavin Production: A Review |
title_sort | metabolic engineering of i bacillus subtilis i for riboflavin production a review |
topic | riboflavin biosynthesis <i>Bacillus subtilis</i> metabolic engineering |
url | https://www.mdpi.com/2076-2607/11/1/164 |
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