Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast

An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple ind...

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Bibliographic Details
Main Authors: Matthew M. Crane, Mitsuhiro Tsuchiya, Ben W. Blue, Jared D. Almazan, Kenneth L. Chen, Siobhan R. Duffy, Alexandra Golubeva, Annaiz M. Grimm, Alison M. Guard, Shauna A. Hill, Ellen Huynh, Ryan M. Kelly, Michael Kiflezghi, Hyunsung D. Kim, Mitchell Lee, Ting-I. Lee, Jiayi Li, Bao M.G. Nguyen, Riley M. Whalen, Feng Y. Yeh, Mark McCormick, Brian K. Kennedy, Joe R. Delaney, Matt Kaeberlein
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-01-01
Series:Translational Medicine of Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501119300380

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http://www.sciencedirect.com/science/article/pii/S2468501119300380

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