Oncogene-independent resistance in Philadelphia chromosome - positive (Ph+) acute lymphoblastic leukemia (ALL) is mediated by activation of AKT/mTOR pathway

Oncogene-independent resistance in Philadelphia chromosome - positive (Ph+) acute lymphoblastic leukemia (ALL) is mediated by activation of AKT/mTOR pathway

Tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, dasatinib, and ponatinib have significantly improved the life expectancy of Philadelphia chromosome-positive (Ph+) acute lymphocytic leukemia (ALL) patients; however, resistance to TKIs remains a major clinical challenge. Point mutations...

Full description

Bibliographic Details
Main Authors: Afsar Ali Mian, Usva Zafar, Syed Muhammad Areeb Ahmed, Oliver Gerhard Ottmann, El-Nasir M A Lalani
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Adult Acute Lymphoblastic Leukemia
4E-BP1
AKT/mTOR pathway
BCR-ABL1
Oncogene independent resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000646

Internet

http://www.sciencedirect.com/science/article/pii/S1476558621000646

Similar Items