Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas

Inhibitory NKG2A+ and absent activating NKG2C+ NK cell responses are associated with the development of EBV+ lymphomas

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, which infects over 90% of the adult human population worldwide. After primary infections, EBV is recurrently reactivating in most adult individuals. It is, however, unclear, why these EBV reactivations progress to EBV+ Hodgkin (EBV+HL) or non-Hod...

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Bibliographic Details
Main Authors: Hannes Vietzen, Philipp B. Staber, Sarah M. Berger, Philippe L. Furlano, Laura M. Kühner, Simone Lubowitzki, Alexander Pichler, Robert Strassl, Jan J. Cornelissen, Elisabeth Puchhammer-Stöckl
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
EBV - Epstein-Barr virus
NK cells
LMP-1
EBV+ lymphoma
immune evasion
HLA-E polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183788/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183788/full

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