Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule

Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule

Kinesins are microtubule-based motor proteins that play important roles ranging from intracellular transport to cell division. Human Kinesin-5 (Eg5) is essential for mitotic spindle assembly during cell division. By combining molecular dynamics (MD) simulations with other multi-scale computational a...

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Bibliographic Details
Main Authors: Wenhan Guo, Shengjie Sun, Jason E. Sanchez, Alan E. Lopez-Hernandez, Tolulope A. Ale, Jiawei Chen, Tanjina Afrin, Weihong Qiu, Yixin Xie, Lin Li
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Kinesin-5
Eg5
Tubulin
Microtubule
Electrostatic features
DelPhi
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003543

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022003543

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