Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

Abstract The mechanisms underlying Parkinson’s disease (PD) etiology are only partially understood despite intensive research conducted in the field. Recent evidence suggests that early neurodevelopmental defects might play a role in cellular susceptibility to neurodegeneration. To study the early d...

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Bibliographic Details
Main Authors: Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nickels, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Sergiy Velychko, Thomas Rauen, Hans R. Schöler, Silvia Bolognin, Thomas Sauter, Javier Jarazo, Rejko Krüger, Jens C. Schwamborn
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00616-8

Internet

https://doi.org/10.1038/s41531-023-00616-8

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