YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response

YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response

ObjectiveThe role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated in rheumatoid arthritis (RA).MethodsFibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured in 2D or into 3D synovial organoids. Arthritis rat model (n=28) a...

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Bibliographic Details
Main Authors: Robin Caire, Estelle Audoux, Guillaume Courbon, Eva Michaud, Claudie Petit, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Arnaud Vanden-Bossche, Laurent Navarro, Marie-Thérèse Linossier, Sylvie Peyroche, Alain Guignandon, Laurence Vico, Stephane Paul, Hubert Marotte
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
YAP
mechanotransduction
inflammation
rheumatoid arthritis
inflammatory bowel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.791907/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.791907/full

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