The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.

The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.

The Orb CPEB protein regulates translation of localized mRNAs in Drosophila ovaries. While there are multiple hypo- and hyperphosphorylated Orb isoforms in wild type ovaries, most are missing in orb(F303), which has an amino acid substitution in a buried region of the second RRM domain. Using a prot...

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Bibliographic Details
Main Authors: Li Chin Wong, Alexandre Costa, Ian McLeod, Ali Sarkeshik, John Yates, Saw Kyin, David Perlman, Paul Schedl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949709/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949709/?tool=EBI

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