Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease

Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease

Abstract The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS by T cells and natural killer T cells (NKTs). To evaluate the potential of target...

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Bibliographic Details
Main Authors: Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman, Eliezer Masliah
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Subjects:
α-synuclein
T cell
Parkinson’s disease
Dementia with Lewy bodies
Adaptive immunity
Innate immunity
Online Access:https://doi.org/10.1186/s12974-024-03087-7

Internet

https://doi.org/10.1186/s12974-024-03087-7

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