Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury

Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury

Cyp2c70 is the liver enzyme in rodents responsible for synthesis of the primary 6-hydroxylated muricholate bile acid (BA) species. Cyp2c70 KO mice are devoid of protective, hydrophilic muricholic acids, leading to a more human-like BA composition and subsequent cholestatic liver injury. Pharmacologi...

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Bibliographic Details
Main Authors: Jennifer K. Truong, Ashley L. Bennett, Caroline Klindt, Ajay C. Donepudi, Sudarshan R. Malla, Kimberly J. Pachura, Alex Zaufel, Tarek Moustafa, Paul A. Dawson, Saul J. Karpen
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Lipid Research
Subjects:
Cytochrome P450
cholesterol 7α-hydroxylase
sterol 12α-hydroxylase
hydrophobicity
detergency
enterohepatic circulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000943

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http://www.sciencedirect.com/science/article/pii/S0022227522000943

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