Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects

Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects

Abstract Background Congenital heart defects (CHD) are structural defects of the heart affecting approximately 1% of newborns. They exhibit low penetrance and non-Mendelian patterns of inheritance as varied and complex traits. While genetic factors are known to play an important role in the developm...

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Bibliographic Details
Main Authors: Martin Broberg, Minna Ampuja, Samuel Jones, Tiina Ojala, Otto Rahkonen, Riikka Kivelä, James Priest, FinnGen, Aarno Palotie, Hanna M. Ollila, Emmi Helle
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Genomics
Subjects:
Genetics
Congenital heart disease
Genome-wide association study
Single nucleotide polymorphisms
Online Access:https://doi.org/10.1186/s12864-024-10172-x

Internet

https://doi.org/10.1186/s12864-024-10172-x

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