Structure-based directed evolution improves S. cerevisiae growth on xylose by influencing in vivo enzyme performance

Abstract Background Efficient bioethanol production from hemicellulose feedstocks by Saccharomyces cerevisiae requires xylose utilization. Whereas S. cerevisiae does not metabolize xylose, engineered strains that express xylose isomerase can metabolize xylose by converting it to xylulose. For this,...

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Bibliographic Details
Main Authors: Misun Lee, Henriëtte J. Rozeboom, Eline Keuning, Paul de Waal, Dick B. Janssen
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Biotechnology for Biofuels
Subjects:
Online Access:https://doi.org/10.1186/s13068-019-1643-0