Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish

Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish

Hirschsprung disease (HSCR) has a higher incidence in children with Down syndrome (DS), which makes trisomy 21 a predisposing factor to HSCR. DSCAM and BACE2 are close together on the HSCR-associated critical region of chromosome 21. Common variants of DSCAM and rare variants of BACE2 were implicate...

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Bibliographic Details
Main Authors: Yan-Jiao Lu, Wen-Wen Yu, Meng-Meng Cui, Xian-Xian Yu, Huan-Lei Song, Mei-Rong Bai, Wen-Jie Wu, Bei-Lin Gu, Jun Wang, Wei Cai, Xun Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hirschsprung disease
DSCAM
BACE2
zebrafish model
enteric nervous system
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641152/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.641152/full

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