Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies

Abstract Host organisms use different innate immune mechanisms to defend against pathogenic infections, while tight control of innate immunity is essential for proper immune induction and balance. Here, we reported that apoptotic induction or caspase-3 overexpression caused dramatic reduction of dif...

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Bibliographic Details
Main Authors: Di Wu, Zhaowei Wang, Jing Zhang, Adam G. Robinson, Bao Lyu, Ziyu Chen, Chong Wang, Bin Wei, Xiaojun Xia, Qing Zhang, Xi Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05156-2