Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies

Abstract Host organisms use different innate immune mechanisms to defend against pathogenic infections, while tight control of innate immunity is essential for proper immune induction and balance. Here, we reported that apoptotic induction or caspase-3 overexpression caused dramatic reduction of dif...

Full description

Bibliographic Details
Main Authors:	Di Wu, Zhaowei Wang, Jing Zhang, Adam G. Robinson, Bao Lyu, Ziyu Chen, Chong Wang, Bin Wei, Xiaojun Xia, Qing Zhang, Xi Zhou
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-08-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-022-05156-2

Similar Items

Striatin translocates to the cytosol of apoptotic cells and is proteolytically cleaved in a caspase 3-dependent manner
by: Moni Nader, et al.
Published: (2020-09-01)

Immunoexpression of cleaved caspase-3 shows lower apoptotic area indices in lip carcinomas than in intraoral cancer
by: Ana Flávia Schueler de Assumpção LEITE, et al.

NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells
by: David J. Wang, et al.
Published: (2014-10-01)

An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways.
by: Hatem Elif Kamber Kaya, et al.
Published: (2017-02-01)

TEGDMA (Triethylene Glycol Dimethacrylate) Induces Both Caspase-Dependent and Caspase-Independent Apoptotic Pathways in Pulp Cells
by: Bálint Viktor Lovász, et al.
Published: (2021-02-01)

Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules
by: Ashif Iqubal, et al.
Published: (2023-12-01)

ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation
by: Shan-Shan Zhang, et al.
Published: (2022-05-01)

Peanut triacylglycerols activate innate immunity both in insects and mammals
by: Wenyuan Li, et al.
Published: (2022-05-01)

Correction: Caspase-1-Like Regulation of the proPO-System and Role of ppA and Caspase-1-Like Cleaved Peptides from proPO in Innate Immunity.
by: Miti Jearaphunt, et al.
Published: (2016-05-01)

Apoptotic cells induce NF-κB and inflammasome negative signaling.
by: Amir Grau, et al.
Published: (2015-01-01)

Decay constant of $$B_s$$ Bs and $$B^*_s$$ Bs∗ mesons from $$\mathrm{N_f}=2$$ Nf=2 lattice QCD
by: Rahul Balasubramamian, et al.
Published: (2020-05-01)

Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
by: Pei-Feng Liu, et al.
Published: (2017-01-01)

Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development
by: Forrest Weghorst, et al.
Published: (2020-11-01)

Total and caspase-cleaved cytokeratin 18 in chronic cholecystitis: A prospective study
by: Polychronidis Alexandros, et al.
Published: (2008-05-01)

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
by: Liang Yan, et al.
Published: (2021-07-01)

NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.
by: Hai-Jie Yang, et al.
Published: (2015-01-01)

NF-κB in innate neuroprotection and age-related neurodegenerative diseases
by: Annamaria eLanzillotta, et al.
Published: (2015-05-01)

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.
by: Hu, Y, et al.
Published: (2015)

Axonal cleaved caspase-3 regulates axon targeting and morphogenesis in the developing auditory brainstem
by: Sarah E Rotschafer, et al.
Published: (2016-10-01)

(-)-Epigallocatechin-3-gallate protects against NO-induced ototoxicity through the regulation of caspase- 1, caspase-3, and NF-κB activation.
by: Su-Jin Kim, et al.
Published: (2012-01-01)

Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
by: Lai, Y, et al.
Published: (2009)

Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way?
by: Daniela Saggioro
Published: (2011-06-01)

A YoeB toxin cleaves both RNA and DNA
by: Julia McGillick, et al.
Published: (2021-02-01)

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
by: You Ke, et al.
Published: (2016-09-01)

Apoptotic caspases cut down the immunogenicity of radiation
by: Aitziber Buqué, et al.
Published: (2019-11-01)

Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis
by: Bin Lei, et al.
Published: (2017-01-01)

TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas
by: Huizhi Wang, et al.
Published: (2020-02-01)

Caspase-Cleaved Keratin 18 Measurements Identified Ongoing Liver Injury after Bariatric Surgery
by: Felix Hempel, et al.
Published: (2021-03-01)

Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.
by: Ryan J Day, et al.
Published: (2015-01-01)

High Serum Caspase-Cleaved Cytokeratin-18 Levels and Mortality of Traumatic Brain Injury Patients
by: Leonardo Lorente, et al.
Published: (2019-10-01)

Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.
by: Katharine G Harris, et al.
Published: (2015-01-01)

Severity of asthma: the role of CD25+,CD30+, NF-κB, and apoptotic markers
by: Abdulamir, Ahmed Sahib, et al.
Published: (2009)

Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways
by: Sambucetti Lidia C, et al.
Published: (2005-10-01)

Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages.
by: Attinder Chadha, et al.
Published: (2021-09-01)

Cigarette smoking induces the activation of RIP2/caspase-12/NF-κB axis in oral squamous cell carcinoma
by: Yajie Qian, et al.
Published: (2022-11-01)

Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
by: Fábio França Vieira e Silva, et al.
Published: (2022-10-01)

Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation
by: Yuanbang Lin, et al.
Published: (2023-10-01)

Activation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis
by: Eva Svandova, et al.
Published: (2018-03-01)

NF-κB, a culprit of both inflamm-ageing and declining immunity?
by: Preeyaporn Songkiatisak, et al.
Published: (2022-05-01)

N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways
by: Huang Lijun, et al.
Published: (2022-08-01)