Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorption activity. Nicorandil (NIC) is a vasodilatory ant...

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Bibliographic Details
Main Authors: Shenggui Xu, Xiankun Cao, Zhenxing Yu, Wenxin He, Yichuan Pang, Wang Lin, Zhiqian Chen, Weizhong Guo, Xiongwei Lu, Chengshou Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
nicorandil
osteoclast
nuclear factor kappa-B
phospho-p38 (p-p38)
ovariectomy
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.726361/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.726361/full

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