Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon’s two-stage trial

Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon’s two-stage trial

Introduction Curative intent treatment of head and neck cancer (HNC) is frequently radiation therapy over 7 weeks with concurrent chemotherapy. This regimen is effective but carries a burden of toxicity leading to severe pain and treatment breaks portending inferior outcomes. Conventional palliation...

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Bibliographic Details
Main Authors: Nagashree Seetharamu, Diana Martins-Welch, Nina Kohn, Joseph Herman, Daniel Koffler, Jacob Eckstein, Maged Ghaly, Louis Potters, Douglas Frank, Kevin Sullivan, Bhupesh Parashar
Format: Article
Language:English
Published: BMJ Publishing Group 2023-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/4/e064809.full

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https://bmjopen.bmj.com/content/13/4/e064809.full

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