Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the s...

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Bibliographic Details
Main Authors: Nathanael G Lintner, Kim F McClure, Donna Petersen, Allyn T Londregan, David W Piotrowski, Liuqing Wei, Jun Xiao, Michael Bolt, Paula M Loria, Bruce Maguire, Kieran F Geoghegan, Austin Huang, Tim Rolph, Spiros Liras, Jennifer A Doudna, Robert G Dullea, Jamie H D Cate
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5360235?pdf=render

Internet

http://europepmc.org/articles/PMC5360235?pdf=render

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