Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term overall survival is just 22%. More than 40 years ago intralesion...

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Bibliographic Details
Main Authors: Jessica Da Gama Duarte, Sagun Parakh, Miles C. Andrews, Katherine Woods, Anupama Pasam, Candani Tutuka, Simone Ostrouska, Jonathan M. Blackburn, Andreas Behren, Jonathan Cebon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
melanoma
bacillus Calmette–Guerin
ipilimumab
immune-related adverse events
protein microarrays
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00411/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00411/full

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