IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts. In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 c...

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Bibliographic Details
Main Authors: Xueyan Zhao, Ruixuan Huo, Xiaolong Yan, Tianjun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
IRF3
TRIF
NF-κB
negative regulation
ubiquitination
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00867/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00867/full

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