The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease
Purpose: Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it’s less discussed in typical Alzheimer’s disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity. Method...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223001055 |
| _version_ | 1827925836689309696 |
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| author | Jiaying Lu Zhengwei Zhang Ping Wu Xiaoniu Liang Huiwei Zhang Jimin Hong Christoph Clement Tzu-Chen Yen Saineng Ding Min Wang Zhenxu Xiao Axel Rominger Kuangyu Shi Yihui Guan Chuantao Zuo Qianhua Zhao |
| author_facet | Jiaying Lu Zhengwei Zhang Ping Wu Xiaoniu Liang Huiwei Zhang Jimin Hong Christoph Clement Tzu-Chen Yen Saineng Ding Min Wang Zhenxu Xiao Axel Rominger Kuangyu Shi Yihui Guan Chuantao Zuo Qianhua Zhao |
| author_sort | Jiaying Lu |
| collection | DOAJ |
| description | Purpose: Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it’s less discussed in typical Alzheimer’s disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity. Methods: Two independent cohorts consisting of patients with mild cognitive impairment due to AD and AD dementia with tau PET imaging were enrolled [the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort with 18F-Flortaucipir, the Shanghai Memory Study (SMS) cohort with 18F-Florzolotau]. Based on the absolute global tau interhemispheric differences, each cohort was divided into two groups (asymmetric versus symmetric tau distribution). The two groups were cross-sectionally compared in terms of demographic, cognitive characteristics, and pathological burden. The cognitive decline trajectories were analyzed longitudinally. Results: Fourteen (23.3%) and 42 (48.3%) patients in the ADNI and SMS cohorts showed an asymmetric tau distribution, respectively. An asymmetric tau distribution was associated with an earlier age at disease onset (proportion of early-onset AD: ADNI/SMS/combined cohorts, p = 0.093/0.026/0.001) and more severe pathological burden (i.e., global tau burden: ADNI/SMS cohorts, p < 0.001/= 0.007). And patients with an asymmetric tau distribution were characterized by a steeper cognitive decline longitudinally (i.e., the annual decline of Mini-Mental Status Examination score: ADNI/SMS/combined cohorts, p = 0.053 / 0.035 / < 0.001). Conclusions: Asymmetry in tau deposition, which may be associated with an earlier age at onset, more severe pathological burden, and a steeper cognitive decline, is potentially an important characteristic of AD heterogeneity. |
| first_indexed | 2024-03-13T05:28:47Z |
| format | Article |
| id | doaj.art-c8c91bb39c3d40c780063f1e0ff35478 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:28:47Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c8c91bb39c3d40c780063f1e0ff354782023-06-15T04:55:55ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103416The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s diseaseJiaying Lu0Zhengwei Zhang1Ping Wu2Xiaoniu Liang3Huiwei Zhang4Jimin Hong5Christoph Clement6Tzu-Chen Yen7Saineng Ding8Min Wang9Zhenxu Xiao10Axel Rominger11Kuangyu Shi12Yihui Guan13Chuantao Zuo14Qianhua Zhao15Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China; Department of Nuclear Medicine, Inselspital Bern, University Hospital, University of Bern, Bern, SwitzerlandDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine, Inselspital Bern, University Hospital, University of Bern, Bern, SwitzerlandDepartment of Nuclear Medicine, Inselspital Bern, University Hospital, University of Bern, Bern, SwitzerlandAPRINOIA Therapeutics Co., Ltd, Suzhou, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaShanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China; Department of Informatics, Technische Universität München, Munich, GermanyDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine, Inselspital Bern, University Hospital, University of Bern, Bern, SwitzerlandDepartment of Nuclear Medicine, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland; Department of Informatics, Technische Universität München, Munich, GermanyDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; Corresponding authors at: Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai 200235, China (C. Zuo, Y. Guan); Department of Neurology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China (Q. Zhao).Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; Corresponding authors at: Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai 200235, China (C. Zuo, Y. Guan); Department of Neurology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China (Q. Zhao).Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China; Corresponding authors at: Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai 200235, China (C. Zuo, Y. Guan); Department of Neurology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China (Q. Zhao).Purpose: Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it’s less discussed in typical Alzheimer’s disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity. Methods: Two independent cohorts consisting of patients with mild cognitive impairment due to AD and AD dementia with tau PET imaging were enrolled [the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort with 18F-Flortaucipir, the Shanghai Memory Study (SMS) cohort with 18F-Florzolotau]. Based on the absolute global tau interhemispheric differences, each cohort was divided into two groups (asymmetric versus symmetric tau distribution). The two groups were cross-sectionally compared in terms of demographic, cognitive characteristics, and pathological burden. The cognitive decline trajectories were analyzed longitudinally. Results: Fourteen (23.3%) and 42 (48.3%) patients in the ADNI and SMS cohorts showed an asymmetric tau distribution, respectively. An asymmetric tau distribution was associated with an earlier age at disease onset (proportion of early-onset AD: ADNI/SMS/combined cohorts, p = 0.093/0.026/0.001) and more severe pathological burden (i.e., global tau burden: ADNI/SMS cohorts, p < 0.001/= 0.007). And patients with an asymmetric tau distribution were characterized by a steeper cognitive decline longitudinally (i.e., the annual decline of Mini-Mental Status Examination score: ADNI/SMS/combined cohorts, p = 0.053 / 0.035 / < 0.001). Conclusions: Asymmetry in tau deposition, which may be associated with an earlier age at onset, more severe pathological burden, and a steeper cognitive decline, is potentially an important characteristic of AD heterogeneity.http://www.sciencedirect.com/science/article/pii/S2213158223001055AsymmetryTauPositron emission tomographyAlzheimer’s diseaseAgePrognosis |
| spellingShingle | Jiaying Lu Zhengwei Zhang Ping Wu Xiaoniu Liang Huiwei Zhang Jimin Hong Christoph Clement Tzu-Chen Yen Saineng Ding Min Wang Zhenxu Xiao Axel Rominger Kuangyu Shi Yihui Guan Chuantao Zuo Qianhua Zhao The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease NeuroImage: Clinical Asymmetry Tau Positron emission tomography Alzheimer’s disease Age Prognosis |
| title | The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease |
| title_full | The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease |
| title_fullStr | The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease |
| title_full_unstemmed | The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease |
| title_short | The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer’s disease |
| title_sort | heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in alzheimer s disease |
| topic | Asymmetry Tau Positron emission tomography Alzheimer’s disease Age Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223001055 |
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