Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development

Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development

Abstract Background Diverse molecular alterations associated with smoking in normal and precursor lung cancer cells have been reported, yet their role in lung cancer etiology remains unclear. A prominent example is hypomethylation of the aryl hydrocarbon-receptor repressor (AHRR) locus, which is obs...

Full description

Bibliographic Details
Main Authors: Yuting Chen, Martin Widschwendter, Andrew E. Teschendorff
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Genome Biology
Subjects:
Smoking
Cancer
EWAS
Transcription factor
Regulatory network
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s13059-017-1366-0

Internet

http://link.springer.com/article/10.1186/s13059-017-1366-0

Similar Items